Article

LRRK2 G2019S disrupts GABAergic signaling and shifts excitatory/inhibitory balance in the striatum

2025-10-24

Abstract excerpt

The excitatory/inhibitory (E/I) balance within neural circuits is essential for proper brain function, and its disruption is a hallmark of several neurodegenerative diseases. In Parkinson’s disease (PD), widespread alterations in the basal ganglia circuitry lead to an E/I imbalance in the striatum, contributing to excitotoxicity. Leucine-rich repeat kinase 2 (LRRK2) has recently emerged as a key contributor to bot...

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Literature Corpus work: d36d3c0e-ea0f-5c43-91ac-f761bb214c30
DOI: 10.1101/2025.10.23.684189

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