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Article

Pharmacological antagonism of kainate receptor rescues dysfunction and loss of dopamine neurons in a mouse model of human parkin-induced toxicity.

Cell death & disease - 10 Nov 2020

Regoni Maria, Cattaneo Stefano, Mercatelli Daniela, Novello Salvatore, Passoni Alice, Bagnati Renzo, Davoli Enrico, Croci Laura, Consalez Gian Giacomo, Albanese Federica, Zanetti Letizia, Passafaro Maria, Serratto Giulia Maia, Di Fonzo Alessio, Valtorta Flavia, Ciammola Andrea, Taverna Stefano, Morari Michele, Sassone Jenny

Abstract excerpt

Mutations in the PARK2 gene encoding the protein parkin cause autosomal recessive juvenile Parkinsonism (ARJP), a neurodegenerative disease characterized by dysfunction and death of dopamine (DA) neurons in the substantia nigra pars compacta (SNc). Since a neuroprotective therapy for ARJP does not exist, research efforts aimed at discovering targets for neuroprotection are critically needed. A previous study...

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Identifiers

PMID: 33173027
DOI: 10.1038/s41419-020-03172-8
PMCID: PMC7656261

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Pharmacological antagonism of kainate receptor rescues dysfunction and loss of dopamine neurons in a mouse model of human parkin-induced toxicity.PMID 33173027Read ↗

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