Article

Parkinson’s disease gene, Synaptojanin1, dysregulates the basal maintenance of the dopamine transporter

2024-03-13

Abstract excerpt

<title>Abstract</title> <p>Missense mutations of PARK20/SYNJ1 (synaptojanin1/Synj1) have been linked to complex forms of familial parkinsonism, however, the molecular and cellular changes associated with dopaminergic dysfunction remains unknown. We now report fast depletion of evoked dopamine (DA) and altered maintenance of the axonal dopamine transporter (DAT) in the Synj1+/- neurons. While Synj1 has been tradit...

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Literature Corpus work: 66145f36-0809-5ae2-bd37-e93ab612a0b4
DOI: 10.21203/rs.3.rs-4021466/v1

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