Article
Parkinson's disease-linked Parkin mutations impair glutamatergic signaling in hippocampal neurons.
BMC biology - 10 Sept 2018
Zhu Mei, Cortese Giuseppe P, Waites Clarissa L
Abstract excerpt
BACKGROUND: Parkinson's disease (PD)-associated E3 ubiquitin ligase Parkin is enriched at glutamatergic synapses, where it ubiquitinates multiple substrates, suggesting that its mutation/loss-of-function could contribute to the etiology of PD by disrupting excitatory neurotransmission. Here, we evaluate the impact of four common PD-associated Parkin point mutations (T240M, R275W, R334C, G430D) on glutamatergic...
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