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Article

The synaptic function of parkin.

Brain : a journal of neurology - 1 Sept 2017

Sassone Jenny, Serratto GiuliaMaia, Valtorta Flavia, Silani Vincenzo, Passafaro Maria, Ciammola Andrea

Abstract excerpt

Loss of function mutations in the gene PARK2, which encodes the protein parkin, cause autosomal recessive juvenile parkinsonism, a neurodegenerative disease characterized by degeneration of the dopaminergic neurons localized in the substantia nigra pars compacta. No therapy is effective in slowing disease progression mostly because the pathogenesis of the disease is yet to be understood. From accruing evidence...

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Identifiers

PMID: 28335015
DOI: 10.1093/brain/awx006

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The synaptic function of parkin.PMID 28335015Read ↗

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Synaptotagmin-11 is a critical mediator of parkin-linked neurotoxicity and Parkinson's disease-like pathology.Semantic proximity Read ↗

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The role of parkin in familial and sporadic Parkinson's disease.Semantic proximity Read ↗

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Diverse Functions of Parkin in Midbrain Dopaminergic Neurons.Semantic proximity Read ↗

Parkinson’s disease-linked Parkin mutations impair glutamatergic synaptic transmission and plasticitySemantic proximity Read ↗

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