Article

Kir4.2 deficiency drives progressive Parkinson’s disease-like motor, cognitive and neuropathological phenotypes in mice

2026-03-03

Abstract excerpt

A critical barrier to therapeutic development in Parkinson’s disease (PD) is the lack of endogenous genetic models that spontaneously recapitulate the disease’s progressive, anatomically selective nigrostriatal pathology. Genetic studies have linked KCNJ15 , encoding the inwardly rectifying potassium channel Kir4.2, to familial PD via a loss-of-function dominant-negative variant; however, its mechanistic role in...

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Literature Corpus work: bcc8e424-e849-5ec8-9733-ac2ac480cbbb
DOI: 10.64898/2026.03.01.708908

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