Article

Alternative polyadenylation is a determinant of oncogenic Ras function

2020-06-10

Abstract excerpt

<h4>ABSTRACT</h4> Alternative polyadenylation of pre-mRNA has been recently shown to play important roles in development and cancer. Activating mutations in the Ras oncogene are common drivers of many human cancers but the mechanisms by which they cooperate with alternative polyadenylation are not known. By exploiting the genetics of C. elegans , we identified cfim-1/CFIm25 , a subunit of the alternative polyad...

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Literature Corpus work: ea6f93ad-c9d2-5f22-8c85-5f739d417f93
DOI: 10.1101/2020.06.08.140145

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