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Article

Cell Cycle Regulation by Alternative Polyadenylation of CCND1.

Scientific reports - 1 May 2018

Wang Qiong, He Guopei, Hou Mengmeng, Chen Liutao, Chen Shangwu, Xu Anlong, Fu Yonggui

Abstract excerpt

Global shortening of 3'UTRs by alternative polyadenylation (APA) has been observed in cancer cells. However, the role of APA in cancer remains unknown. CCND1 is a proto-oncogene that regulates progression through the G1-S phase of the cell cycle; moreover, it has been observed to be switching to proximal APA sites in cancer cells. To investigate the biological function of the APA of CCND1, we edited the weak...

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Identifiers

PMID: 29717174
DOI: 10.1038/s41598-018-25141-0
PMCID: PMC5931507

Genes

CCND1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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