Article

The splicing kinase PRPF-4 is required for somatic development and germline function in <i>C. elegans</i>

2026-08-31

Abstract excerpt

Pre-mRNA splicing is essential for gene expression, yet how disruption of core spliceosomal factors produces tissue- and developmental stage-specific phenotypes remains poorly understood. Here, we investigated the in vivo function of the conserved spliceosomal kinase PRPF-4 in C. elegans using endogenous reporter analysis, conditional protein depletion, and transcriptome-wide analysis of alternative splicing and...

Identifiers and source

Literature Corpus work: ab313579-f1e9-531c-9586-5a0f5946ae6f
DOI: 10.64898/2026.08.28.747746

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