Article
Comprehensive single cell profiling of ageing glial cells reveals impaired Wnt signalling and Jun transcription factors regulating cortical astrocytes
2026-04-17
Abstract excerpt
Understanding age-related cellular dysfunction in the brain is essential for developing strategies to promote healthy ageing. Towards this aim, we took advantage of a previously established mild dissociation method to profile cells in the cerebral cortex grey matter of adult and aged mice. This revealed glial cells with largely up-regulated and other glia and neurons with largely down-regulated gene expression upo...
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Identifiers and source
- Literature Corpus work
- ea4bc9eb-1f78-5f36-8464-9cd3ed5313c7
- DOI
- 10.64898/2026.04.16.718928