Article

Combinatorial transcription factor profiles predict mature and functional human islet α and β cells

2021-02-24

Abstract excerpt

<h4>ABSTRACT</h4> Islet-enriched transcription factors (TFs) exert broad control over cellular processes in pancreatic α and β cells and changes in their expression are associated with developmental state and diabetes. However, the implications of heterogeneity in TF expression across islet cell populations are not well understood. To define this TF heterogeneity and its consequences for cellular function, we pro...

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Literature Corpus work: ea461062-4320-5384-96fd-067cd7f5dec8
DOI: 10.1101/2021.02.23.432522

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