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Combinatorial transcription factor profiles predict mature and functional human islet α and β cells

24 Aug 2021

Abstract excerpt

Islet-enriched transcription factors (TFs) exert broad control over cellular processes in pancreatic α and β cells, and changes in their expression are associated with developmental state and diabetes. However, the implications of heterogeneity in TF expression across islet cell populations are not well understood. To define this TF heterogeneity and its consequences for cellular function, we profiled more than...

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PMID: 34428183
DOI: 10.1172/jci.insight.151621

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