Article

Chromatin accessibility differences between alpha, beta, and delta cells identifies common and cell type-specific enhancers

2021-12-06

Abstract excerpt

High throughput sequencing has enabled the interrogation of the transcriptomic landscape of glucagon-secreting alpha cells, insulin-secreting beta cells, and somatostatin-secreting delta cells. These approaches have furthered our understanding of expression patterns that define healthy or diseased islet cell types and helped explicate some of the intricacies between major islet cell crosstalk and glucose regulatio...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5f5c8012-ac01-5d31-98f8-95dd19e0c244
DOI: 10.1101/2021.12.06.471006

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Chromatin accessibility differences between alpha, beta, and delta cells identifies common and cell type-specific enhancersDOI 10.1101/2021.12.06.471006Read

Chromatin accessibility differences between alpha, beta, and delta cells identifies common and cell type-specific enhancersSemantic proximity Read

Integration of ATAC-seq and RNA-seq identifies human alpha cell and beta cell signature genesSemantic proximity Read

Epigenetic Profiling of Human Insulinomas Reveals AP-1 Family as Critical Regulators of Beta Cell MaturationSemantic proximity Read

Latent plasticity of the human pancreas across development, health, and diseaseSemantic proximity Read

Genes Associated with Pancreas Development and Function Maintain Open Chromatin in iPSCs Generated from Human Pancreatic Beta CellsSemantic proximity Read

Epigenomic plasticity enables human pancreatic α to β cell reprogrammingSemantic proximity Read

A Chromatin Basis for Cell Lineage and Disease Risk in the Human Pancreas.Semantic proximity Read

Alpha TC1 and Beta-TC-6 genomic profiling uncovers both shared and distinct transcriptional regulatory features with their primary islet counterpartsSemantic proximity Read

Defining the chromatin and transcriptional landscape of stem cell-derived isletsSemantic proximity Read

Combinatorial transcription factor profiles predict mature and functional human islet α and β cellsSemantic proximity Read

Islet cells share promoter hypomethylation independently of expression, but exhibit cell-type–specific methylation in enhancersSemantic proximity Read

Single cell chromatin accessibility reveals pancreatic islet cell type- and state-specific regulatory programs of diabetes riskSemantic proximity Read