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Single cell multiomic analysis reveals diabetes-associated β-cell heterogeneity driven by HNF1A

5 Sept 2023

Abstract excerpt

Broad heterogeneity in pancreatic β-cell function and morphology has been widely reported. However, determining which components of this cellular heterogeneity serve a diabetes-relevant function remains challenging. Here, we integrate single-cell transcriptome, single-nuclei chromatin accessibility, and cell-type specific 3D genome profiles from human islets and identify Type II Diabetes (T2D)-associated β-cell...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 37669939
DOI: 10.1038/s41467-023-41228-3

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