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Integration of ATAC-seq and RNA-seq identifies human alpha cell and beta cell signature genes

11 Jan 2016

Abstract excerpt

OBJECTIVE: Although glucagon-secreting α-cells and insulin-secreting β-cells have opposing functions in regulating plasma glucose levels, the two cell types share a common developmental origin and exhibit overlapping transcriptomes and epigenomes. Notably, destruction of β-cells can stimulate repopulation via transdifferentiation of α-cells, at least in mice, suggesting plasticity between these cell fates....

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PMID: 26977395
DOI: 10.1016/j.molmet.2016.01.002

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