Article

Resource misallocation as a mediator of fitness costs in antibiotic resistance

2018-10-30

Abstract excerpt

<h4>Summary</h4> Antimicrobial resistance poses a threat to global health and the economy. It is widely accepted that, in the absence of antibiotics, drug resistance mutations carry a fitness cost. In the case of rifampicin resistance in fast-growing bacteria, this cost stems from a reduced transcription rate of the RNA polymerase resulting in slower ribosome biosynthesis. However, this relationship does not appl...

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Literature Corpus work: ea3daef1-b16d-5c36-9c19-20ebd13b68d0
DOI: 10.1101/456434

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