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Article

Whole-genome sequencing of rifampicin-resistant Mycobacterium tuberculosis strains identifies compensatory mutations in RNA polymerase genes.

Nature genetics - 18 Dec 2011

Comas Iñaki, Borrell Sonia, Roetzer Andreas, Rose Graham, Malla Bijaya, Kato-Maeda Midori, Galagan James, Niemann Stefan, Gagneux Sebastien

Abstract excerpt

Epidemics of drug-resistant bacteria emerge worldwide, even as resistant strains frequently have reduced fitness compared to their drug-susceptible counterparts. Data from model systems suggest that the fitness cost of antimicrobial resistance can be reduced by compensatory mutations; however, there is limited evidence that compensatory evolution has any significant role in the success of drug-resistant bacteria...

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Share to DNA-Directed RNA Polymerases
Share to Drug Resistance, Bacterial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome, Bacterial

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Share to Tuberculosis, Multidrug-Resistant

Source

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Identifiers

PMID: 22179134
DOI: 10.1038/ng.1038
PMCID: PMC3246538

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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