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Article

Drug resistance, fitness and compensatory mutations in Mycobacterium tuberculosis.

Tuberculosis (Edinburgh, Scotland) - 1 Jul 2021

Alame Emane Amel Kevin, Guo Xujun, Takiff Howard E, Liu Shengyuan

Abstract excerpt

For tuberculosis to be eradicated, the transmission of Multi-Drug-Resistant and eXtensively Drug Resistant strains of Mycobacterium tuberculosis (MDR and XDR-TB) must be considerably reduced. Drug resistant strains were initially thought to have reduced fitness, and the majority of resistant strains may actually have compromised fitness because they are found in only one or a few patients. In contrast, some...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 34090078
DOI: 10.1016/j.tube.2021.102091

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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