Article
Analysing the fitness cost of antibiotic resistance to identify targets for combination antimicrobials.
Nature microbiology - 1 Nov 2021
Rasouly Aviram, Shamovsky Yosef, Epshtein Vitaly, Tam Kayan, Vasilyev Nikita, Hao Zhitai, Quarta Giulio, Pani Bibhusita, Li Lingting, Vallin Carmen, Shamovsky Ilya, Krishnamurthy Shankarling, Shtilerman Aaron, Vantine Samantha, Torres Victor J, Nudler Evgeny
Abstract excerpt
Mutations in the rifampicin (Rif)-binding site of RNA polymerase (RNAP) confer antibiotic resistance and often have global effects on transcription that compromise fitness and stress tolerance of resistant mutants. We suggested that the non-essential genome, through its impact on the bacterial transcription cycle, may represent an untapped source of targets for combination antimicrobial therapies. Using...
Topics
- Anti-Bacterial Agents
- Bacteria
- Bacterial Proteins
- DNA-Directed RNA Polymerases
- Drug Resistance, Bacterial
- Genome, Bacterial
- Mutation
- Rifampin
- Transcription, Genetic