Article

Antibiotic resistance evasion is explained by rare mutation frequency and not by lack of compensatory mechanisms

2018-07-23

Abstract excerpt

Drug resistant infections represent one of the most challenging medical problems of our time. D-cycloserine is an antibiotic used for decades without appearance and dissemination of antibiotic resistant strains, making it an ideal model compound to understand what drives resistance evasion. We investigated why Mycobacterium tuberculosis fails to become resistant to D-cycloserine. To address this question we emplo...

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Identifiers and source

Literature Corpus work: 3f33a6b2-4215-5388-8fd0-5d8438eba053
DOI: 10.1101/374215

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