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Article

Rifampicin Resistance: Fitness Costs and the Significance of Compensatory Evolution

3 Apr 2013

Abstract excerpt

Seventy years after the introduction of antibiotic chemotherapy to treat tuberculosis, problems caused by drug-resistance in Mycobacterium tuberculosis have become greater than ever. The discovery and development of novel drugs and drug combination therapies will be critical to managing these problematic infections. However, to maintain effective therapy in the long-term and to avoid repeating the mistakes of the...

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Identifiers

PMID: 27029299
DOI: 10.3390/antibiotics2020206

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Rifampicin Resistance: Fitness Costs and the Significance of Compensatory EvolutionPMID 27029299Read ↗

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Large-scale statistical analysis of Mycobacterium tuberculosis genome sequences identifies compensatory mutations associated with multi-drug resistance.Semantic proximity Read ↗

Insights into the processes that drive the evolution of drug resistance in <i>Mycobacterium tuberculosis</i>Semantic proximity Read ↗

Compensatory mutations are associated with increased in vitro growth in resistant clinical samples of Mycobacterium tuberculosis.Semantic proximity Read ↗

Putative compensatory mutations in the rpoC gene of rifampin-resistant Mycobacterium tuberculosis are associated with ongoing transmission.Semantic proximity Read ↗

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