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Article

Expression Dysregulation as a Mediator of Fitness Costs in Antibiotic Resistance.

Antimicrobial agents and chemotherapy - 17 Aug 2021

Trauner Andrej, Banaei-Esfahani Amir, Gygli Sebastian M, Warmer Philipp, Feldmann Julia, Zampieri Mattia, Borrell Sonia, Collins Ben C, Beisel Christian, Aebersold Ruedi, Gagneux Sebastien

Abstract excerpt

Antimicrobial resistance (AMR) poses a threat to global health and the economy. Rifampicin-resistant Mycobacterium tuberculosis accounts for a third of the global AMR burden. Gaining the upper hand on AMR requires a deeper understanding of the physiology of resistance. AMR often results in a fitness cost in the absence of drug. Identifying the molecular mechanisms underpinning this cost could help strengthen...

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Identifiers

PMID: 34228548
DOI: 10.1128/AAC.00504-21
PMCID: PMC8370218

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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