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Article

Mutations compensating for the fitness cost of rifampicin resistance in Escherichia coli exert pleiotropic effect on RNA polymerase catalysis.

Nucleic acids research - 10 Jun 2022

Kurepina Natalia, Chudaev Maxim, Kreiswirth Barry N, Nikiforov Vadim, Mustaev Arkady

Abstract excerpt

The spread of drug-resistant bacteria represents one of the most significant medical problems of our time. Bacterial fitness loss associated with drug resistance can be counteracted by acquisition of secondary mutations, thereby enhancing the virulence of such bacteria. Antibiotic rifampicin (Rif) targets cellular RNA polymerase (RNAP). It is potent broad spectrum drug used for treatment of bacterial infections....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35639764
DOI: 10.1093/nar/gkac406
PMCID: PMC9177976

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Mutations compensating for the fitness cost of rifampicin resistance in Escherichia coli exert pleiotropic effect on RNA polymerase catalysis.PMID 35639764Read ↗

Mutations in RNA polymerase that drive the emergence of antibiotic resistance.Semantic proximity Read ↗

Whole-genome sequencing of rifampicin-resistant Mycobacterium tuberculosis strains identifies compensatory mutations in RNA polymerase genes.Semantic proximity Read ↗

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Insights into RNA polymerase catalysis and adaptive evolution gained from mutational analysis of a locus conferring rifampicin resistance.Semantic proximity Read ↗

Rifampicin Resistance: Fitness Costs and the Significance of Compensatory EvolutionSemantic proximity Read ↗

Novel and Reported Compensatory Mutations in <i>rpoABC</i> Associate Specifically with Predominant <i>Mycobacterium tuberculosis</i> Rifampicin Resistance Marker <i>rpoB</i> :S450LSemantic proximity Read ↗

Resource misallocation as a mediator of fitness costs in antibiotic resistanceSemantic proximity Read ↗

Compensatory mutations are associated with increased <i>in vitro</i> growth in resistant clinical samples of <i>Mycobacterium tuberculosis</i>Semantic proximity Read ↗

Analysing the fitness cost of antibiotic resistance to identify targets for combination antimicrobials.Semantic proximity Read ↗

Linking system-wide impacts of RNA polymerase mutations to the fitness cost of rifampin resistance in Pseudomonas aeruginosa.Semantic proximity Read ↗

Fitness-compensatory mutations in rifampicin-resistant RNA polymerase.Semantic proximity Read ↗

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