Article

Pervasive Chromosomal Instability Drives the Karyotypic Evolution of Hypodiploid Tumours

2025-08-12

Abstract excerpt

<h4>ABSTRACT</h4> Tumours frequently exhibit extreme levels of aneuploidy. While increases in ploidy are well-characterised, the opposite phenomenon—extensive chromosome loss leading to hypodiploidy— remains underexplored. Here, we analyse over 17,000 cancer genomes from 34 cancer types and perform a pan-cancer analysis of karyotypic evolution in hypodiploid tumours. We find that hypodiploidy is widespread and as...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ea15f03a-3e4a-5740-9d87-3f10e923d02e
DOI: 10.1101/2025.08.08.668983

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Pervasive Chromosomal Instability Drives the Karyotypic Evolution of Hypodiploid TumoursDOI 10.1101/2025.08.08.668983Read

Clonal origin and development of high hyperdiploidy in childhood acute lymphoblastic leukaemiaSemantic proximity Read

Pan-cancer analysis of single-cell RNA sequencing data from 304 human tumors sheds light on the ‘aneuploidy paradox’Semantic proximity Read

Single cell multi-omics analysis of chromothriptic medulloblastoma highlights genomic and transcriptomic consequences of genome instabilitySemantic proximity Read

Unique mutation and gene expression in High Hyperdiploid Acute Lymphoblastic Leukaemia with whole chromosome uniparental isodisomySemantic proximity Read

Near-Haploidy and Low-Hypodiploidy in B-Cell Acute Lymphoblastic Leukemia: When Less Is Too MuchSemantic proximity Read

Genetic hallmarks and clinical implications of chromothripsis in childhood T-cell acute lymphoblastic leukemiaSemantic proximity Read

The genomic landscape of hypodiploid acute lymphoblastic leukemia.Semantic proximity Read

Genetic and epigenetic characterization of hypodiploid acute lymphoblastic leukemia.Semantic proximity Read

Genetic landscape of high hyperdiploid childhood acute lymphoblastic leukemia.Semantic proximity Read

Adult Low-Hypodiploid Acute Lymphoblastic Leukemia Emerges from Preleukemic TP53-Mutant Clonal Hematopoiesis.Semantic proximity Read

Analysis of genetic abnormalities provides insights into genetic evolution of hyperdiploid myelomaSemantic proximity Read

The genomic landscape of high hyperdiploid childhood acute lymphoblastic leukemia.Semantic proximity Read