Article

Genetic hallmarks and clinical implications of chromothripsis in childhood T-cell acute lymphoblastic leukemia

2024-03-05

Abstract excerpt

<title>Abstract</title> <p>Chromothripsis (cth) is a form of genomic instability leading to massive de novo structural chromosome rearrangements in a one-time catastrophic event. It can cause cancer-promoting alterations, such as loss of sequences for tumor-suppressor genes, formation of oncogenic fusions, and oncogene amplifications. We investigated the genetic background and clinical significance of cth in chil...

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Literature Corpus work: 64107f48-051e-5a2e-b0af-464e7d032e4a
DOI: 10.21203/rs.3.rs-3961467/v1

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