Adult Low-Hypodiploid Acute Lymphoblastic Leukemia Emerges from Preleukemic TP53-Mutant Clonal Hematopoiesis.

doi:10.1158/2643-3230.BCD-22-0154

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Adult Low-Hypodiploid Acute Lymphoblastic Leukemia Emerges from Preleukemic TP53-Mutant Clonal Hematopoiesis.

Blood cancer discovery - 1 Mar 2023

Kim Rathana, Bergugnat Hugo, Larcher Lise, Duchmann Matthieu, Passet Marie, Gachet Stéphanie, Cuccuini Wendy, Lafage-Pochitaloff Marina, Pastoret Cédric, Grardel Nathalie, Asnafi Vahid, Schäfer Beat W, Delabesse Eric, Itzykson Raphaël, Adès Lionel, Hicheri Yosr, Chalandon Yves, Graux Carlos, Chevallier Patrice, Hunault Mathilde, Leguay Thibaut, Huguet Françoise, Lhéritier Véronique, Dombret Hervé, Soulier Jean, Rousselot Philippe, Boissel Nicolas, Clappier Emmanuelle

Abstract excerpt

Low hypodiploidy defines a rare subtype of B-cell acute lymphoblastic leukemia (B-ALL) with a dismal outcome. To investigate the genomic basis of low-hypodiploid ALL (LH-ALL) in adults, we analyzed copy-number aberrations, loss of heterozygosity, mutations, and cytogenetics data in a prospective cohort of Philadelphia (Ph)-negative B-ALL patients (n = 591, ages 18-84 years), allowing us to identify 80 LH-ALL...

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PMID: 36630200
DOI: 10.1158/2643-3230.BCD-22-0154
PMCID: PMC9975768

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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