Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Clonal origin and development of high hyperdiploidy in childhood acute lymphoblastic leukaemia

25 Mar 2023

Abstract excerpt

High hyperdiploid acute lymphoblastic leukemia (HeH ALL), one of the most common childhood malignancies, is driven by nonrandom aneuploidy (abnormal chromosome numbers) mainly comprising chromosomal gains. In this study, we investigate how aneuploidy in HeH ALL arises. Single cell whole genome sequencing of 2847 cells from nine primary cases and one normal bone marrow reveals that HeH ALL generally display low...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Genomics and Diagnostics
Share to Genomic variations and chromosomal abnormalities
Share to Pancreatic and Hepatic Oncology Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36966135
DOI: 10.1038/s41467-023-37356-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clonal origin and development of high hyperdiploidy in childhood acute lymphoblastic leukaemiaPMID 36966135Read ↗

The genomic landscape of high hyperdiploid childhood acute lymphoblastic leukemia.Semantic proximity Read ↗

Pervasive Chromosomal Instability Drives the Karyotypic Evolution of Hypodiploid TumoursSemantic proximity Read ↗

Genetic landscape of high hyperdiploid childhood acute lymphoblastic leukemia.Semantic proximity Read ↗

Single‐cell DNA and surface protein characterization of high hyperdiploid acute lymphoblastic leukemia at diagnosis and during treatmentSemantic proximity Read ↗

High hyperdiploid childhood acute lymphoblastic leukemiaSemantic proximity Read ↗

Cancer drivers and clonal dynamics in acute lymphoblastic leukaemia subtypes.Semantic proximity Read ↗

Aneuploidy in Cancer: Lessons from Acute Lymphoblastic LeukemiaSemantic proximity Read ↗

Cancer drivers and clonal dynamics in acute lymphoblastic leukaemia subtypesSemantic proximity Read ↗

Adult Low-Hypodiploid Acute Lymphoblastic Leukemia Emerges from Preleukemic TP53-Mutant Clonal Hematopoiesis.Semantic proximity Read ↗

Selection forces underlying aneuploidy patterns in cancerSemantic proximity Read ↗

Hyperdiploidy: the longest known, most prevalent, and most enigmatic form of acute lymphoblastic leukemia in children.Semantic proximity Read ↗

Identification of favorable subgroups of childhood high-hyperdiploid acute lymphoblastic leukemia in a modern therapy era – A retrospective international study of 3,231 patientsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.