Article
Single cell multi-omics analysis of chromothriptic medulloblastoma highlights genomic and transcriptomic consequences of genome instability
2021-06-25
Abstract excerpt
<h4>ABSTRACT</h4> Chromothripsis is a form of genome instability, whereby a presumably single catastrophic event generates extensive genomic rearrangements of one or few chromosome(s). However, little is known about the heterogeneity of chromothripsis across different clones from the same tumor, as well as changes in response to treatment. We analyzed single-cell genomic and transcriptomic alterations linked with...
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Identifiers and source
- Literature Corpus work
- b42c66df-05a4-5822-9948-7f456e51acc9
- DOI
- 10.1101/2021.06.25.449944