Article

Unique mutation and gene expression in High Hyperdiploid Acute Lymphoblastic Leukaemia with whole chromosome uniparental isodisomy

2022-02-16

Abstract excerpt

<title>Abstract</title> <p>Whole genome copy number alterations, targeted gene-panel and RNA sequencing were used to investigate differences in high hyperdiploid (HH) B-cell acute lymphoblastic leukemia (ALL), with and without whole chromosome uniparental isodisomy (wUPD). Patients with wUPD demonstrated a higher modal number of chromosomes with gains of chromosome 5. Mutations in genes within epigenetic pathways...

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Literature Corpus work: 702abde6-4efe-5a17-a13a-f1f351530c9c
DOI: 10.21203/rs.3.rs-1349722/v1

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