Article
The genomic landscape of hypodiploid acute lymphoblastic leukemia.
Nature genetics - 1 Mar 2013
Holmfeldt Linda, Wei Lei, Diaz-Flores Ernesto, Walsh Michael, Zhang Jinghui, Ding Li, Payne-Turner Debbie, Churchman Michelle, Andersson Anna, Chen Shann-Ching, McCastlain Kelly, Becksfort Jared, Ma Jing, Wu Gang, Patel Samir N, Heatley Susan L, Phillips Letha A, Song Guangchun, Easton John, Parker Matthew, Chen Xiang, Rusch Michael, Boggs Kristy, Vadodaria Bhavin, Hedlund Erin, Drenberg Christina, Baker Sharyn, Pei Deqing, Cheng Cheng, Huether Robert, Lu Charles, Fulton Robert S, Fulton Lucinda L, Tabib Yashodhan, Dooling David J, Ochoa Kerri, Minden Mark, Lewis Ian D, To L Bik, Marlton Paula, Roberts Andrew W, Raca Gordana, Stock Wendy, Neale Geoffrey, Drexler Hans G, Dickins Ross A, Ellison David W, Shurtleff Sheila A, Pui Ching-Hon, Ribeiro Raul C, Devidas Meenakshi, Carroll Andrew J, Heerema Nyla A, Wood Brent, Borowitz Michael J, Gastier-Foster Julie M, Raimondi Susana C, Mardis Elaine R, Wilson Richard K, Downing James R, Hunger Stephen P, Loh Mignon L, Mullighan Charles G
Abstract excerpt
The genetic basis of hypodiploid acute lymphoblastic leukemia (ALL), a subtype of ALL characterized by aneuploidy and poor outcome, is unknown. Genomic profiling of 124 hypodiploid ALL cases, including whole-genome and exome sequencing of 40 cases, identified two subtypes that differ in the severity of aneuploidy, transcriptional profiles and submicroscopic genetic alterations. Near-haploid ALL with 24-31...
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