Article

Immortalized AT2 Cell Lines from Healthy and IPF Lungs Enable 2D and 3D Cultures

2026-03-09

Abstract excerpt

Idiopathic pulmonary fibrosis (IPF) is characterized by impaired alveolar type 2 cell regeneration. However, robust in vitro models of human distal lung epithelium are limited. In this study, we generated immortalized AT2 cell lines from healthy and IPF lungs using HTII-280 sorting and SV40 large T antigen transduction. These lines retain key features of alveolar epithelial biology in both 2D and 3D cultures, incl...

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Literature Corpus work: ea09f5a1-dfda-5070-bc56-0676789f6072
DOI: 10.64898/2026.03.09.709900

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