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Human pluripotent stem cell‐derived lung organoids: Potential applications in development and disease modeling

3 Nov 2020

Abstract excerpt

The pulmonary system is comprised of two main compartments, airways and alveolar space. Their tissue and cellular complexity ensure lung function and protection from external agents, for example, virus. Two-dimensional (2D) in vitro systems and animal models have been largely employed to elucidate the molecular mechanisms underlying human lung development, physiology, and pathogenesis. However, neither of these...

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PMID: 33145915
DOI: 10.1002/wdev.399

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