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Article

Co-culture of human AT2 cells with fibroblasts reveals a MUC5B phenotype: insights from an organoid model.

Molecular medicine (Cambridge, Mass.) - 23 Nov 2024

Yao Yiwen, Ritzmann Felix, Miethe Sarah, Kattler-Lackes Kathrin, Colakoglu Betül, Herr Christian, Kamyschnikow Andreas, Brand Michelle, Garn Holger, Yildiz Daniela, Langer Frank, Bals Robert, Beisswenger Christoph

Abstract excerpt

Impaired interaction of fibroblasts with pneumocytes contributes to the progression of chronic lung disease such as idiopathic pulmonary fibrosis (IPF). Mucin 5B (MUC5B) is associated with IPF. Here we analyzed the interaction of primary fibroblasts and alveolar type 2 (AT2) pneumocytes in the organoid model. Single-cell analysis, histology, and qRT-PCR revealed that fibroblasts expressing high levels of fibrosis...

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Share to Alveolar Epithelial Cells
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39578767
DOI: 10.1186/s10020-024-00990-w
PMCID: PMC11585087

Genes

MUC5B
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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