Article

Human Alveolar Type II Organoids from Fibrotic Lungs Capture Disease-Specific Metabolic Reprogramming and Provide a Platform for Personalized Medicine

2025-11-04

Abstract excerpt

<title>Abstract</title> <p> <bold>Background</bold> Alveolar type II (AT-II) epithelial cells are essential for alveolar repair, immune regulation, and surfactant secretion. Despite their promise for pulmonary disease modeling, limited access and culture methods hinder translational use. We established a patient-derived 3D AT-II organoid system from fibrotic and non-fibrotic lung tissue to maintain AT-II identi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a9fc2f85-6b63-52b8-a35f-27d0e41a7a2c
DOI: 10.21203/rs.3.rs-7913465/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Human Alveolar Type II Organoids from Fibrotic Lungs Capture Disease-Specific Metabolic Reprogramming and Provide a Platform for Personalized MedicineDOI 10.21203/rs.3.rs-7913465/v1Read

Optimized culture of primary human alveolar type II cell-derived 3D organoids from fibrotic lung tissue with phenotypic and metabolic profiling.Semantic proximity Read

Standardized pipeline for establishing, expanding, and differentiating airway and alveolar organoids from human BAL fluidSemantic proximity Read

Immortalized AT2 Cell Lines from Healthy and IPF Lungs Enable 2D and 3D CulturesSemantic proximity Read

A single cell atlas of in vitro multi-systems uncovers in vivo lineage trajectory and cell state in the human lungSemantic proximity Read

Modeling cell-cell interactions to advance drug discovery in Idiopathic Pulmonary FibrosisSemantic proximity Read

Robust generation of distal respiratory airway organoids by an engineered cuboid chip to therapy chronic obstructive pulmonary diseaseSemantic proximity Read

Adult Stem Cell-derived Complete Lung Organoid Models Emulate Lung Disease in COVID-19Semantic proximity Read

Alveolar wars: The rise of in vitro models to understand human lung alveolar maintenance, regeneration, and diseaseSemantic proximity Read

Design, infectability, and transcriptomic analysis of transregionally differentiated and scalable lung organoids derived from adult bronchial cellsSemantic proximity Read

A single-cell atlas of in vitro multiculture systems uncovers the in vivo lineage trajectory and cell state in the human lungSemantic proximity Read

Impact of cell culture on the transcriptomic programs of primary and iPSC-derived human alveolar type 2 cellsSemantic proximity Read

Isolation, Culture, and Phenotypic Analysis of Murine Lung Organoids.Semantic proximity Read