Article
Optimized culture of primary human alveolar type II cell-derived 3D organoids from fibrotic lung tissue with phenotypic and metabolic profiling.
Respiratory research - 7 Mar 2026
Schröder Lara-Jasmin, Rückoldt Julia, Schubert Stephanie, Knudsen Lars, Janciauskiene Sabina-Marija, Werlein Christopher, Knoll Mareike, Engelhardt Regina, Petzold-Mügge Christina, Schupp Jonas C, Hoeper Marius M, Gottlieb Jens, Ius Fabio, Zardo Patrick, Lindenberg Marc, Riehle Christian, Neubert Lavinia, Kamp Jan C
Abstract excerpt
BACKGROUND: Alveolar type II (AT-II) epithelial cells are essential for alveolar repair, immune regulation, and surfactant secretion. Despite their promise for pulmonary disease modeling, limited access and culture methods hinder translational use. We established a patient-derived 3D AT-II organoid system from fibrotic and non-fibrotic lung tissue to maintain AT-II-associated features, enable cryopreservation,...
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