Article

Mutual information networks reveal evolutionary relationships within the influenza A virus polymerase

2023-02-17

Abstract excerpt

The influenza A (IAV) RNA polymerase is an essential driver of IAV evolution. Mutations that the polymerase introduces into viral genome segments during replication are the ultimate source of genetic variation, including within the three subunits of the IAV polymerase (PB2, PB1, and PA). Evolutionary analysis of the IAV polymerase is complicated, because changes in mutation rate, replication speed, and drug resist...

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Literature Corpus work: e9e491f4-4d8c-5e76-ab81-98d8391588fa
DOI: 10.1101/2023.02.16.528850

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