Article

Deep mutational scanning reveals the functional constraints and evolutionary potential of the influenza A virus PB1 protein

2023-08-27

Abstract excerpt

The influenza virus polymerase is central to influenza virus evolution. Adaptive mutations within the polymerase are often a prerequisite for efficient spread of novel animal-derived viruses in human populations. The polymerase also determines fidelity, and therefore the rate at which the virus will acquire mutations that lead to host range expansion, drug resistance, or antigenic drift. Despite its importance to...

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Literature Corpus work: d2f98ba0-bb0b-5499-872d-bb47d15cb826
DOI: 10.1101/2023.08.27.554986

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