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Article

Variations outside the conserved motifs of PB1 catalytic active site may affect replication efficiency of the RNP complex of influenza A virus.

Virology - 1 Jul 2021

Waters Kaitlyn, Wan Hamilton J, Han Lei, Xue Jianli, Ykema Matthew, Tao Yizhi J, Wan Xiu-Feng

Abstract excerpt

PB1 functions as the catalytic subunit of influenza virus RNA polymerase complex and plays an essential role in viral RNA transcription and replication. To determine plasticity in the PB1 enzymatic site and map catalytically important residues, 658 mutants were constructed, each with one to seven mutations in the enzymatic site of PB1. The polymerase activities of these mutants were quantified using a minigenome...

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Identifiers

PMID: 33887645
DOI: 10.1016/j.virol.2021.04.001
PMCID: PMC8579824

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