Combining mutual information with structural analysis to screen for functionally important residues in influenza hemagglutinin.

Abstract excerpt

Influenza hemagglutinin mediates both cell-surface binding and cell entry by the virus. Mutations to hemagglutinin are thus critical in determining host species specificity and viral infectivity. Previous approaches have primarily considered point mutations and sequence conservation; here we develop a complementary approach using mutual information to examine concerted mutations. For hemagglutinin, several...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Binding Sites
• Share to Biometry
• Share to Crystallography, X-Ray