Identification of human-to-human transmissibility factors in PB2 proteins of influenza A by large-scale mutual information analysis

Abstract excerpt

BACKGROUND: The identification of mutations that confer unique properties to a pathogen, such as host range, is of fundamental importance in the fight against disease. This paper describes a novel method for identifying amino acid sites that distinguish specific sets of protein sequences, by comparative analysis of matched alignments. The use of mutual information to identify distinctive residues responsible for...

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