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Article

Large-scale sequence analysis reveals novel human-adaptive markers in PB2 segment of seasonal influenza A viruses.

Emerging microbes & infections - 29 Mar 2018

Wen Lei, Chu Hin, Wong Bosco Ho-Yin, Wang Dong, Li Cun, Zhao Xiaoyu, Chiu Man-Chun, Yuan Shuofeng, Fan Yanhui, Chen Honglin, Zhou Jie, Yuen Kwok-Yung

Abstract excerpt

To elucidate the adaptive strategies of influenza A viruses (IAVs) to human, we proposed a computational approach to identify human-adaptive mutations in seasonal IAVs, which have not been analyzed comprehensively. We compared representative PB2 sequences of 1425 avian IAVs and 2176 human IAVs and identified a total of 42 human-adaptive markers, including 28 and 31 markers in PB2 proteins of seasonal viruses H1N1...

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Source

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Identifiers

PMID: 29593225
DOI: 10.1038/s41426-018-0050-0
PMCID: PMC5874250

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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