Article

Biophysical analysis reveals autophosphorylation as an important negative regulator of LRRK2 dimerization

2023-08-11

Abstract excerpt

Leucine-rich repeat kinase 2 (LRRK2) is a large, multi-domain protein which is associated with Parkinson’s disease. Although high-resolution structures of LRRK2 are available, little is known about the complex dynamics behind the inter-domain regulation of LRRK2 and its perturbation by pathogenic variants. Previous studies have demonstrated that LRRK2 goes through an oligomerization cycle at the membrane, however...

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Literature Corpus work: e9dc1498-a4f0-589d-9bb6-764c24aba576
DOI: 10.1101/2023.08.11.549911

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