Article
Insight into the mode of action of the LRRK2 Y1699C pathogenic mutant.
Journal of neurochemistry - 1 Jan 2011
Daniëls Veronique, Vancraenenbroeck Renée, Law Bernard M H, Greggio Elisa, Lobbestael Evy, Gao Fangye, De Maeyer Marc, Cookson Mark R, Harvey Kirsten, Baekelandt Veerle, Taymans Jean-Marc
Abstract excerpt
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most prevalent known cause of autosomal dominant Parkinson's disease. The LRRK2 gene encodes a Roco protein featuring a Ras of complex proteins (ROC) GTPase and a kinase domain linked by the C-terminal of ROC (COR) domain. Here, we explored the effects of the Y1699C pathogenic LRRK2 mutation in the COR domain on GTPase activity and interactions...
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