Article
A homologue of the Parkinson's disease-associated protein LRRK2 undergoes a monomer-dimer transition during GTP turnover.
Nature communications - 18 Oct 2017
Deyaert Egon, Wauters Lina, Guaitoli Giambattista, Konijnenberg Albert, Leemans Margaux, Terheyden Susanne, Petrovic Arsen, Gallardo Rodrigo, Nederveen-Schippers Laura M, Athanasopoulos Panagiotis S, Pots Henderikus, Van Haastert Peter J M, Sobott Frank, Gloeckner Christian Johannes, Efremov Rouslan, Kortholt Arjan, Versées Wim
Abstract excerpt
Mutations in LRRK2 are a common cause of genetic Parkinson's disease (PD). LRRK2 is a multi-domain Roco protein, harbouring kinase and GTPase activity. In analogy with a bacterial homologue, LRRK2 was proposed to act as a GTPase activated by dimerization (GAD), while recent reports suggest LRRK2 to exist under a monomeric and dimeric form in vivo. It is however unknown how LRRK2 oligomerization is regulated....
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