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Markov State Models and Molecular Dynamics Simulations Provide Understanding of the Nucleotide-Dependent Dimerization-Based Activation of LRRK2 ROC Domain.

Molecules (Basel, Switzerland) - 17 Sept 2021

Li Xinyi, Qi Zengxin, Ni Duan, Lu Shaoyong, Chen Liang, Chen Xiangyu

Abstract excerpt

Mutations in leucine-rich repeat kinase 2 (LRRK2) are recognized as the most frequent cause of Parkinson's disease (PD). As a multidomain ROCO protein, LRRK2 is characterized by the presence of both a Ras-of-complex (ROC) GTPase domain and a kinase domain connected through the C-terminal of an ROC domain (COR). The bienzymatic ROC-COR-kinase catalytic triad indicated the potential role of GTPase domain in...

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Share to GTP Phosphohydrolases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34577121
DOI: 10.3390/molecules26185647
PMCID: PMC8467336

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