Article

Gene fusions during the early evolution of mesothelioma correlate with impaired DNA repair and Hippo pathways

2023-04-25

Abstract excerpt

Malignant pleural mesothelioma (MPM), a rare cancer a long latency period (up to 40 years) between asbestos exposure and disease presentation. The mechanisms coupling asbestos to recurrent somatic alterations are poorly defined. Gene-fusions arising through genomic instability may create novel drivers during early MPM evolution. We explored the gene fusions that occurred early in the evolutionary history. We condu...

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Literature Corpus work: e9c8ebfc-c8ad-58e1-b972-7e6119ed3e28
DOI: 10.1101/2023.04.20.23288867

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