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Article

Whole exome sequencing of an asbestos-induced wild-type murine model of malignant mesothelioma.

BMC cancer - 2 Jun 2017

Sneddon Sophie, Patch Ann-Marie, Dick Ian M, Kazakoff Stephen, Pearson John V, Waddell Nicola, Allcock Richard J N, Holt Robert A, Robinson Bruce W S, Creaney Jenette

Abstract excerpt

BACKGROUND: Malignant mesothelioma (MM) is an aggressive cancer of the pleural and peritoneal cavities caused by exposure to asbestos. Asbestos-induced mesotheliomas in wild-type mice have been used extensively as a preclinical model because they are phenotypically identical to their human counterpart. However, it is not known if the genetic lesions in these mice tumours are similar to in the human disease, a...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28577549
DOI: 10.1186/s12885-017-3382-6
PMCID: PMC5455120

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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