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Article

BAP1 mutation is a frequent somatic event in peritoneal malignant mesothelioma.

Journal of translational medicine - 16 Apr 2015

Alakus Hakan, Yost Shawn E, Woo Brian, French Randall, Lin Grace Y, Jepsen Kristen, Frazer Kelly A, Lowy Andrew M, Harismendy Olivier

Abstract excerpt

BACKGROUND: Malignant mesothelioma (MM) arises from mesothelial cells that line the pleural, peritoneal and pericardial surfaces. The majority of MMs are pleural and have been associated with asbestos exposure. Previously, pleural MMs have been genetically characterized by the loss of BAP1 (40-60%) as well as loss of NF2 (75%) and CDKN2A (60%). The rare peritoneal form of MM occurs in ~10% cases. With only ~300...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25889843
DOI: 10.1186/s12967-015-0485-1
PMCID: PMC4422481

Genes

BAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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BAP1 mutation is a frequent somatic event in peritoneal malignant mesothelioma.PMID 25889843Read ↗

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