The emerging complexity of gene fusions in cancer.

Abstract excerpt

Structural chromosome rearrangements may result in the exchange of coding or regulatory DNA sequences between genes. Many such gene fusions are strong driver mutations in neoplasia and have provided fundamental insights into the disease mechanisms that are involved in tumorigenesis. The close association between the type of gene fusion and the tumour phenotype makes gene fusions ideal for diagnostic purposes,...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cytogenetic Analysis
• Share to Gene Expression Regulation, Neoplastic
• Share to Gene Fusion