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Article

Whole exome and targeted deep sequencing identify genome-wide allelic loss and frequent SETDB1 mutations in malignant pleural mesotheliomas.

Oncotarget - 16 Feb 2016

Kang Hio Chung, Kim Hong Kwan, Lee Sharon, Mendez Pedro, Kim James Wansoo, Woodard Gavitt, Yoon Jun-Hee, Jen Kuang-Yu, Fang Li Tai, Jones Kirk, Jablons David M, Kim Il-Jin

Abstract excerpt

Malignant pleural mesothelioma (MPM), a rare malignancy with a poor prognosis, is mainly caused by exposure to asbestos or other organic fibers, but the underlying genetic mechanism is not fully understood. Genetic alterations and causes for multiple primary cancer development including MPM are unknown. We used whole exome sequencing to identify somatic mutations in a patient with MPM and two additional primary...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Loss of Heterozygosity

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Source

Open in PubMed Open full text

Identifiers

PMID: 26824986
DOI: 10.18632/oncotarget.7032
PMCID: PMC4884995

Genes

SETDB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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